Prepare three shallow dishes for a breading station. In the first, whisk together the flour, salt, pepper, garlic powder, onion powder, and paprika. In the second, beat the eggs. In the third, spread out the Panko breadcrumbs.

Pat each tilapia fillet completely dry with paper towels. This step is crucial for a crispy coating.

Working one fillet at a time, dredge in the seasoned flour, shaking off excess. Dip into the egg wash, letting excess drip off. Finally, press firmly into the Panko breadcrumbs to coat completely.

Preheat your air fryer to 400°F (200°C) for at least 5 minutes.

Lightly spray the air fryer basket with olive oil spray. Place two fillets in the basket in a single layer, not overlapping. Lightly spray the tops of the fillets with olive oil spray.

Air fry for 10-12 minutes, flipping carefully halfway through. The fish is done when the crust is golden brown and the internal temperature reaches 145°F (63°C).

Remove from the air fryer and serve immediately. Repeat with the remaining fillets.